Since publication of the NICE-SUGAR trial, this meta-analysis of 26 trials found no overall mortality benefit to tight glucose control in ICU patients. They did find a mortality benefit in the subset of surgical ICU patients (RR 0.63, CI 0.44-0.91). However, the overall risk of hypoglycemia (<40) was markedly higher in tight glucose control group (RR 6, CI 4.5-8.0). Outside of the surgical ICU, tight glucose control appears to do more harm than good (abstract).
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March 26, 2009 |
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About the Author: Danielle Scheurer
Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.
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