In this trial of 200 patients with active Cdiff infection, they were randomized to placebo or a single IV infusion of a monoclonal antibody against toxin A and B, in addition to standard treatment with either metronidazole or vancomycin. Those in the antibody group had lower risk of recurrence at 84 days (7% vs 25%) with no difference in adverse events. A single infusion of monoclonal antibody significantly reduces the risk of recurrent Cdiff infection (abstract).
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