In the highly anticipated NICE-SUGAR trial, over 6000 med-surg ICU patients from 42 hospitals were randomized to tight (81-108) or conventional (<180) glucose control. The primary outcome (90 day death) occurred in 28% of the tight, versus 25% of the conventional group, and severe hypoglycemia (<40) occurred in 7% versus <1%. Tight glucose control in adult ICU patients may be harmful, and goals should be liberalized to keep glucose 140-180 (time-weighted mean in the conventional group was 142) (abstract)
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