This meta-analysis found that the risk of both hospital and community acquired pneumonia is significantly higher in those on PPI or H2 blockers. This is the strongest evidence to date of the risk elevation of pneumonia in these drugs (adjusted OR range 1.22 to 1.27), which should not be presribed without an definitive indication (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]