An FDA working group has recommended changes to acetaminophen dosing, to reduce the risk of accidental liver injury. Some of these include reducing the recommended maximum dose to 650mg, reducing the maximum daily dose to 3250mg (and lower for those who drink 3 or more alcoholic beverages a day), as well as eliminating the use of combination products. An FDA advisory committee is scheduled to meet in late June to review these changes, so stay tuned (FDA report).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]