No gentamycin for staph endocarditis

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By  |  February 19, 2009 | 

Low dose “synergistic” gentamycin has been traditionally used in conjunction with anti-staph penicillins or vancomycin to treat staph aureus endocarditis, however the nephrotoxicity of this practice had not been evaluated. In this prospective cohort of safety data from a randomized trial of patients with staph aureus endocarditis, researchers found that 22% of those that received gentamycin, versus only 8% that did not, suffered a decrease in their creatinine clearance. Given the limited efficacy of low dose gent synergy, the authors and an accompanying editorial conclude that the risks outweigh the benefits (abstract)

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About the Author: Danielle Scheurer

Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.

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