In trial of 106 patients with respiratory failure, immediately post-extubation they were randomized to non-invasive ventilation (for 24 hours) or conventional oxygen. Those in the non-invasive ventilation group were less likely to have respiratory failure at 72 hours (15% vs 48%), and had lower 90 day mortality (11% vs 31%) (where most of the causes of death were due to respiratory failure). A 24 hour trial of non-invasive ventilation post-extubation may reduce respiratory failure and mortality (abstract).
My patient was a 69 year old lady with metastatic small cell lung cancer. She was on experimental chemotherapy and was admitted from clinic with worsening lower extremity edema and a new oxygen requirement. She underwent a chest and abdominal CT that revealed new pulmonary masses, tumor and a mass invading her right pulmonary artery, […]
The large multi-center ICU trial randomized ICUs to 1 of 3 strategies: MRSA screening/isolation, MRSA screening/isolation/decolonization, or global decolonization (5 days BID nasal mupiricin and daily chlorhexidine bathing). The hazard ratios for MRSA isolates in the 3 groups were 0.92, 0.75, 0.63 respectively. The hazard ratios for any bloodstream infection in the 3 groups were […]
This trial found no difference in patient outcomes (mortality or LOS) if admitted during a time of 24/7 intensivist coverage, or during a time with only daytime intensivist coverage (with home call at night) in a medical ICU. This study does not show a patient benefit to a 24/7 intensivist staffing model in an academic […]