In this population based cohort study of patients with chronic non-cancer pain on opioids, the total daily dose was linearly correlated with the risk of unintentional death (with about twice the odds of death in those with doses between 50mg-200mg equivalent of morphine, and with about three times the odds of death in those with doses>200mg/day). Patients at morphine equivalents of >50mg a day should be regularly followed, sign and adhere to pain contracts, and be counseled about the risk of unintentional death (abstract)
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