There is controversy about whether PPIs reduce the clinical efficacy of clopidogrel. In this large cohort in Denmark of patients discharged after an MI, those discharged on a PPI had an increased risk of MI/stroke/CV death, regardless of whether or not they were discharged on clopidogrel, and there was no statistical interaction between PPI and clopidogrel. This study implies that it is the PPI, not the co-administration of PPI and clopidogrel, that increased the CV risk post MI (abstract)
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