In this open label trial, 235 patients with a history of hepatic encephalopathy were randomized to placebo, lactulose tid, or probiotics tid. Within 12 months of follow up, hepatic encephalopathy developed in 38 placebo patients, 22 probiotic patients, and 18 lactulose patients. Although a small trial, this suggests that probiotics may be added to the options for secondary prevention of hepatic encephalopathy (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]