In this large prospective cohort of patients presenting to an ED with chest pain of suspected cardiac origin, those with 3 negative findings (EKG without ischemia, normal cardiac biomarkers, and TIMI risk of zero), the 30 day risk of major cardiac adverse events was <1% (negative predictive value of 99.1%). Most patients with these 3 negative findings can be safety discharged with a low risk of short term cardiac events (abstract)
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