In this large trial of patients undergoing ERCP, they were randomized to a single dose of rectal indomethacin or placebo immediately after the procedure; pancreatitis occurred in7 1% of those with placebo, and 9% of those with indomethacin (and moderate-to-severe pancreatitis occurred in 9% and 4% of patients, respectively). In patients at risk for post-ERCP pancreatitis, post procedure rectal indomethacin can almost halve the risk (abstract)
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