In this large meta-analysis of 61 randomized controlled trials, low dose ASA increased the risk of major GI bleeding by over 55% (OR 1.55, CI 1.27-1.90); but compared to low dose ASA, clopidogrel and anticoagulants almost doubled the odds of major GI bleeding (OR 1.86 and 1.93, respectively). The addition of a PPI to low dose ASA reduced the risk of major GI bleeding by 2/3 (OR 0.34, CI 0.21-0.57). This meta-analysis helps quantify the risks of GI bleeding with these 3 agents (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]