In this single institution study, the implementation of a hard stop to medication ordering (of concomitant warfarin and trimethoprim-sulfamethoxazole) resulted in significant reductions in the co-ordering of the 2 medications, but also resulted in clinically significant delays in appropriate medication use in 4 patients. The risk and benefit of hard stops, and anticipating unintended consequences, should be thoroughly investigated before the implementation of CPOE hard stops (abstract).
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