Patients with moderate to severe Cdiff are commonly treated with oral vancomycin, but there has been a theoretical concern of rectal VRE transmission from these patients. In this prospective observational study of patients with Cdiff and concurrent VRE colonization, researchers cultured skin and environmental samples from patients before, during, and after treatment with vancomycin or metronidazole. They found no difference in VRE-positive skin or environmental cultures between the 2 treatment groups, indicating VRE contamination from oral-vancomycin-treated patients should not be a substantial concern (abstract).
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