This large observational study of ~125,000 patients on warfarin for Afib found the rate of bleeding to be ~4% per person-year (which is higher than rates reported in randomized controlled trials). Bleeding was highest in the first 30 days (12%), and much higher in the first 30 days in those with a CHADS2 score of 4+ (17%). In addition, over 5 years, 9% of patients were admitted for bleeding, and 18% of those died in the hospital, or within 7 days of discharge (abstract).
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