In this large randomized trial of patients with systolic CHF and normal sinus rhythm, those randomized to warfarin had lower rates of ischemic stroke (hazard ratio 0.52, CI 0.33 to 0.82), but higher rates of major bleeding (1.8 versus 0.9 events per 100 patient years), compared to ASA. The decision between warfarin and ASA in CHF patients with normal sinus rhythm should be based on risk of stroke and bleeding, without a one-size-fits-all approach (abstract)
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