BNP vs. symptom-guided CHF management

By  |  January 28, 2009 | 

In this multicenter trial of 500 patients >age 60, patients were randomized to CHF medical titration based on symptoms alone (goal NYHA class <2), or symptoms + BNP (goal of <2 times upper limit of normal). There was no difference in 18 month quality of life, overall survival, or survival free hospitalizations, but the BNP-guided group did have fewer CHF hospitalizations (62% vs 72%) (only found in those <age 75) (abstract). An editorialist advocates using BNP to titrate CHF medications in patients <75 years old (editorialist). Although this was an outpatient study, this data give some credence to the common practice of using BNP measurements to gauge CHF treatment success in the inpatient setting.

About the Author:

Danielle Scheurer
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.


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