In this industry sponsored randomized trial of 1952 healthy adults (aged 18 to 49), the inactivated (intramuscular) vaccine outperformed the live-attenuated (nasal spray). Overall 6% of participants had lab-confirmed influenza, and there was a 50% reduction in influenza cases in the inactivated vaccine group compared to the live-attenuated group. Inactivated seasonal influenza vaccination reduces lab-confirmed influenza more than live-attenuated in healthy adults (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.