In this meta-analysis of randomized trials of inpatients with acute CHF exacerbations, lasix by continuous infusion resulted in greater weight loss (~0.8kg) and greater urine output (~240cc/day/100mg lasix) compared to IV boluses, but did not differ in urinary sodium excretion or length of stay. Due to lack of differences in clinical endpoints, deciding on bolus versus continuous infusions for now may be based on logistics (eg continuous infusion availability, cost, and convenience) (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.