IV diuretic dose and schedule does not affect CHF outcomes

By  |  March 2, 2011 | 

In this randomized trial of hospitalized CHF patients, they were randomized to IV bolus or continuous infusion of furosemide, at either low dose (equivalent to home dose) or high dose (equivalent to 2.5 times the home dose). At 72 hours, there was no significant difference in patient symptoms or serum creatinine between the dosing groups or the schedule groups. The high dose strategy was favorable in diuresis and some secondary outcomes, but at the expense of a transient increase in serum creatinine (abstract). There is no apparent advantage to continuous IV furosemide versus bolus dosing; there may be some advantage to higher diuretic doses (2.5 times equivalent home dose).

About the Author:

Danielle Scheurer
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.


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