In this case control study from the Acute Liver Failure Study Group registry, researchers determined that the combination of 3 simple lab tests diagnosed Wilson’s disease as a cause of acute liver failure with a sensitivity and specificity of 100%. These included AST:ALT ratio >2.2, alkaline phosphatase:total bilirubin ratio <4, and ceruloplasmin <20 mg/dL. Although this combination needs to be validated prospectively, this is an easy way to narrow the differential in patients presenting with acute liver failure (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.