In this large retrospective cohort of >32,000 patients with 4 common diagnoses with moderate to high risk of VTE, about half received LMWH and half UFH. There were no differences between the groups in rates of VTE, bleeding or cost, but UFH was associated 2.8 times the odds of a complication requiring discontinuation compared to LMWH. This large systematic review found LMWH was associated with lower odds of complications compared to UFH (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.