Another retrospective analysis of patients on acid suppression (H2-PPIs-both) found they had 2.5 times the risk of complications, and almost 5 times the risk of death with Cdiff, compared to those not on these medications (abstract). As such, the FDA has now issued a MedSafety warning on the risk, and advocating using the lowest dose for the shortest time possible (FDA site)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]