There is controversy about whether PPIs reduce the clinical efficacy of clopidogrel. In this large cohort in Denmark of patients discharged after an MI, those discharged on a PPI had an increased risk of MI/stroke/CV death, regardless of whether or not they were discharged on clopidogrel, and there was no statistical interaction between PPI and clopidogrel. This study implies that it is the PPI, not the co-administration of PPI and clopidogrel, that increased the CV risk post MI (abstract)
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.