In thistrial of 120 healthy volunteers, they were randomized to 12 weeks of placebo or 8 weeks of PPI followed by 4 weeks of placebo. GERD symptoms were similar in the first 8 weeks, but in weeks 9-12, symptoms were significantly higher in the former PPI group (44% versus 15%) indicating significant post-PPI rebound. This is another reason to avoid unnecessary PPIs in inpatients, as many will experience rebound symptoms after cessation (abstract).
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.