This large cohort of patients on warfarin who experienced a GI bleed found 59% resumed warfarin within 90 days. Those that resumed were significantly less likely to experience thrombosis (hazard ratio 0.05, CI 0.01-0.58) or death (hazard ratio 0.31, CI 0.15-0.62), and did not have a higher risk of bleeding, compared to those that did not resume warfarin within 90 days. This study suggests that early re-initiation of warfarin after a GI bleed results in better clinical outcomes that waiting for 90 days or later (abstract)
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]