Rifamixin; no apparent superiority for encephalopathy

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By  |  December 8, 2008 | 

In this meta-analysis comparing rifamixin to non-absorbable disaccharides (of which only 5 controlled trials met quality criteria), researchers determined rifamixin was no more effective than non-absorbable disaccharides in treating hepatic encephalopathy (abstract). Although limited by small sample size (only 264 total patients), this is the best evidence to date for first line disaccharides, then rifamixin for failure to improve (given their higher cost).

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About the Author: Danielle Scheurer

Danielle Scheurer, MD, MSCR, SFHM is a clinical hospitalist and the Chief Quality Officer at the Medical University of South Carolina in Charleston, South Carolina, where she also serves as Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She is also the President of SHM's Board of Directors and previously served as Physician Editor of The Hospitalist, SHM's monthly newsmagazine.

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