Which antiplatelet agent for secondary stroke prevention?

By  |  October 23, 2008 | 

In secondary (non-afib) stroke prevention, current guidelines recommend antiplatelet therapy (guideline) but do not give a prefence to which type. In the first head to head trial, the RCT PRoFESS Trial (abstract), randomized 20,332 patients to clopidogrel or ASA-dipyridamole within 4 months of an ischemic stroke. There was no significant difference in recurrent stroke, MI, or death between the groups. This study indicates there is not much difference in efficacy between them, and an accompanying editorial satirically states, in haiku “For stroke prevention / use an antiplatelet drug. / Treat hypertension.” (editorial).

 

About the Author:

Danielle Scheurer
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.

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