In this prospective cohort of 131 patients with stable CHF, 6 BNP measurements were obtained every 4 weeks to determine BNP variability in the setting of stable CHF signs and symptoms (abstract). They found the BNP could triple or fall by a third, with no clinical change in the patient. This gives caution to using BNP as a sole variable in determining the severity of clinical CHF.
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.