In this multicenter trial of patients with arterial or central venous catheters, patients were randomized (2 X2 factorial design) to dressing changes every 3 or 7 days, and to either standard dressings or chlorhexidine gluconate-impregnated sponges (CHGIS). CHGIS reduced catheter-related bloodstream infections from 1.3 to 0.4 (per 1000 catheter days), and the q7 day dressing changes were non-inferior to the q3 day dressing changes (abstract).
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