For first trimester nausea and vomiting, treatment options are limited. In this large retrospective analysis of >81,000 pregnant women, the use of first trimester metoclopramide had no association with congenital malformations, low birth weight, preterm birth, or perinatal death (abstract). This give reassurance of the safety of first trimester metoclopramide use for nausea and vomiting.
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]