New strategy for CIN prevention

By  |  March 18, 2009 | 

We are all aware of the high prevalence of CIN, and the limited utility of currently available agents to prevent it. This trial of 254 patients with baseline creatinine > 1.3 mg/dl undergoing coronary angiography randomized participants to ANP versus lactated ringers (LR) fluids (both for 4-6 hrs before and 48 hours after). The incidence of CIN (>25% or >0.5 mg/dl increase from baseline) occurred in 3% versus 12% of the ANP and LR group (p=0.02), respectively. In multivariate analysis, ANP significantly reduced the incidence of CIN (OR 0.24; p=0.02). If confirmed in larger studies, we may soon be able to add ANP to our preventive strategy arsenal (abstract)

Leave A Comment

About the Author: Danielle Scheurer

Danielle Scheurer
Dr. Scheurer is a clinical hospitalist and the Medical Director of Quality and Safety at the Medical University of South Carolina in Charleston, South Carolina, and is Assistant Professor of Medicine. She is a graduate of the University of Tennessee College of Medicine, completed her residency at Duke University, and completed her Masters in Clinical Research at the Medical University of South Carolina. She also serves as the Web Editor and Physician Advisor for the Society of Hospital Medicine.


Related Posts

By  | June 18, 2018 |  0
Fill in the Blanks: Q: “The diagnosis of type 2 MI is associated with a _____ prognosis.  ___% of patients will live five years after their diagnosis.” The answer is a) POOR and b) a staggering 40%. I did not know that. However, what I am aware of is the ambiguity around Type 2 MIs and […]
By  | July 5, 2016 |  0
What comes to mind when you think of getting CME? I bet most of you would say sitting in an auditorium, whether that be during your local grand rounds or at our professional society meeting, like Hospital Medicine 16 in sunny San Diego this past March. Hanging out in the Twitterverse? Probably not so much… […]
By  | December 3, 2013 |  1
As a nurse practitioner in hospital medicine I have multiple opportunities to interact with all sorts of physician hospitalist colleagues, hospital medicine group leaders, quality officers etc.  Often their interactions with me take on a certain wary curiosity, like I am some exotic monkey or another creature that is unfamiliar to them.  If I am […]