In this meta-analysis comparing rifamixin to non-absorbable disaccharides (of which only 5 controlled trials met quality criteria), researchers determined rifamixin was no more effective than non-absorbable disaccharides in treating hepatic encephalopathy (abstract). Although limited by small sample size (only 264 total patients), this is the best evidence to date for first line disaccharides, then rifamixin for failure to improve (given their higher cost).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]