In this large retrospective cohort from a single VA center, researchers compared the risk of bleeding after polypectomy in patients on or not on plavix. They found the risk of immediate bleeding was the same, but the risk of delayed bleeding (1-4 days) was higher in the plavix group (3.5% vs 1%), which was much higher in those on concomitant ASA or NSAID (with an odds ratio of bleeding of 3.7 in those on concomitant ASA/NSAIDs versus plavix alone). Given the risk of bleeding is higher with plavix, but the absolute risk of bleeding is low, the decision to discontinue plavix before polypectomy should be made on a case by case basis, but concomitant plavix with ASA/NSAID before polypectomy should be avoided (abstract).
This large systematic review found rectal NSAIDs significantly reduced the risk of post-ERCP pancreatitis compared to pancreatic duct stents (abstract).
This large population-based cohort found the most common causes of drug induced liver injury to be augmentin and diclofenac, followed by herbal and nutritional supplements (abstract).
This large trial of patients with a relative contraindication for enteral feeds were randomized to early TPN or usual care. There were no differences in the groups in 60 day mortality or LOS, but those on TPN did have a shorter time ventilated and less muscle/fat loss. It is unclear based on this trial if […]