Researchers analyzed all randomized controlled trials listed in pubmed in 2008 in 3 clinical area (GI, cardiology, and rheumatology) in 10 high impact clinical journals. They found that of the 323 trials, only 46% were adequately registered (registered before the end of the trial with the primary outcome cleared stated). Among those adequately registered, 31% had a discrepancy in the registered primary outcome and the published primary outcome (including omission of the primary outcome, reporting a secondary outcome as primary, and reporting unregistered outcomes as primary). Despite registration requirements for most high impact journals, many trials are not publishing the intended primary outcomes measures (abstract)
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